通过产油微藻培养可实现污泥热水解消化液中高氨氮及磷酸盐的资源化处理，具有工艺简单、运行成本低、资源利用率高等优势。但消化液中含有多种抑藻物质，其中有机类抑制因子是控制的关键和难点。本课题对产油小球藻培养涉及的有机类关键抑制因子识别、影响机理、调控机制等科学问题进行深入研究。通过污泥热水解消化液中有机物全成分分析、有机物定量结构-毒性效应关系模型（QSTR）拓扑分析及抑藻动力学研究，精确识别消化液中有机类关键抑藻因子；通过产油小球藻代谢产物及关键代谢通路分析研究，阐明关键抑制有机物对藻生长与代谢的影响机理；通过生物氧化和高级氧化工艺对关键抑制有机物的降解动力学研究，优化和建立有机类关键抑制因子调控技术体系。本研究对于揭示污泥热水解消化液产油小球藻资源化处理中的风险机制、促进微藻生物质能源技术的发展具有重要的学术价值和现实意义。

Oil-rich microalgae cultivation for removing abundant ammonia and phosphorus from the anaerobic effluent of thermal hydrolyzed sludge (AE-THS) has several advantages to support its development, including simple technological process, low costs and high capacity for nutrients recycling. However, the AE-THS contains several inhibitory substances for microalgal growth, of which these harmful organics is the core issue. Therefore, identification of the key inhibitory organics, the inhibition mechanism and regulatory technology will be investigated in this research. Firstly, the key inhibitory organics for Chlorella pyrenoidosa culture are determined by means of the analysis of total components in the AE-THS, topological analysis of the quantitative structure–toxicity relationship (QSTR) and theoretical analysis about inhibition kinetics. Metabolomic analysis about the microalgae response to the key inhibitory organics will be processed to reveal the mechanism for inhabiting microalgal growth. Finally, degradation kinetics of the key inhibitory organics using different methods and products toxicity to the microalgae are tested to reduce the wastewater toxicity. This research is essential for reducing the inhibitory risks during AE-THS treatment using oil-rich microalgae, and also is helpful to advance the combined technology of wastewater treatment and algal biomass production.