贝壳在损伤后的再生过程是一个动态的生物矿化过程。研究贝壳损伤再生有助于深入了解生物矿化的机理。目前，我们对于贝壳再生过程中的基因调控、蛋白表达模式以及是否有蛋白复合物的参与了解的很少，这限制了我们对于生物矿化动态过程的研究。基于以上科学问题，我们拟以中国重要的海水产珍珠经济种类合浦珠母贝为实验对象，以其贝壳损伤后的再生过程为研究模型，综合利用转录组学、蛋白组学、分子生物学等技术手段，研究贝壳再生过程中的基因表达和蛋白参与模式。本研究工作有助于我们从基因和蛋白水平全面了解生物矿化的过程，揭示贝壳再生过程中基因、蛋白是如何相互作用，共同协调以完成贝壳修复过程。同时，了解这一过程有助于研发新型的生物材料，对于珍珠贝的养殖也具有重要的指导意义。

Self-regeneration of shells after injury is a dynamic process of biomineralization, the study of which will help us to further understand biomineralization. At present, we know little about gene regulation, protein expression patterns and protein complex during the process of shell regeneration, which limits our understanding of the dynamic processes of biomineralization. Based on the above scientific problems, we intend to use the important pearl economic species of Pinctada fucata as the experimental object, and take the regeneration process of shell injury as the research model. By comprehensively using transcriptomics, proteomics, molecular biology and other technical approaches, we plan to study gene regulation, protein expression patterns involved in the process of regenerated shells. This work will help us to understand the processes of biomineralization from different levels, and reveal how genes and proteins interact during shell regeneration, and coordinate the process of shell repair. Moreover, this study may enlighten new biomaterial preparation and provide guidance for pearl oyster culture industry.