血管吻合手术是整形外科手术的基石，所有组织器官的游离移植都需要血管吻合，比如断指修复、血管移植等。吻合手术的难度随着血管直径的减小而上升，如外径小于1毫米的显微血管缝合以及小于0.5毫米的超显微手术一直是临床技术的难点。如今临床亟需一种客观可靠的在术中就能够辅助医生预判血管吻合手术长期成功率的评估工具。傅里叶频域多普勒光学相干层析成像术是一种高分辨率实时无损伤成像系统，在提供血管结构信息的同时还能提供血管内的血流速度。本课题将设计和制造一个方便临床使用的紧凑便携式手持成像探头，通过对血管多角度成像再配准的方法提高血管成像深度，利用多普勒血流信号将血流通道和血栓三维信息进行自动化分割。最后通过建立和完善一个基于血流速度、血流通道以及血栓三维结构信息的计算机数值模型来模拟预测手术的长期成功率，以达到客观信息的整合与手术成功率的准确评估。

Vascular anastomosis is considered to be the foundation of plastic and reconstructive surgery. All tissue or organ transplantation requires vascular anastomosis, such as finger reconstruction and vessel transplantation. The difficulty of the surgery increases with the decreasing of vessel diameter. For example microvascular anastomosis for vessels with diameter less than 1 mm and super microvascular anastomosis for vessels with diameter less than 0.5 mm have always been a challenge clinically. Nowadays there is a strong demand for an intraoperative surgical evaluation tool that can help the surgeons assess the quality of anastomosis and predict the long term surgical outcome objectively and reliably. Fourier domain Doppler optical coherence tomography is a real-time high resolution 3D imaging modality that can provide both structure and flow information of the vessels non-invasively. In this proposal, we will design and fabricate a compact miniature handheld probe that is convenient for surgeons to use during surgery. We propose to increase the image penetration depth of OCT system through angular compounding. We will also perform automatic segmentation of the vessel tunnel and thrombosis region using the Doppler flow information. In the end we will build and optimize an intelligent numerical model that can simulate the long-term surgical outcome as a predication based on the parameters we measure objectively, which include blood flow speed, 3D vessel tunnel and thrombosis structure.