微塑料对四溴双酚A在食用贝类中生物有效性的影响

微塑料作为一种新型环境污染物，由于其在环境水体、沉积物和水生生物中的广泛检出而倍受公众关注。而作为工业塑料阻燃剂的四溴双酚A(TBBPA)会在塑料降解过程中逐渐释放出来，并吸附在微塑料表面。当微塑料被生物体摄食后，TBBPA会与微塑料在水生生物体内共同富集并通过食物链影响人体健康。然而，目前有关微塑料结合TBBPA的生物有效性情况与人体暴露特征尚不明确。本项目在建立微塑料结合TBBPA的定量分析方法基础上，通过微塑料与TBBPA对食用贝类的复合暴露试验，定量分析微塑料对TBBPA在食用贝类中生物富集的影响；并采用体外消化道模型与动物实验相结合的研究方法，探究微塑料对食用贝类中TBBPA生物可给性和生物有效性的作用，揭示微塑料对 TBBPA 的生物有效性的影响及相关机制。本研究可为微塑料结合TBBPA的环境污染水平的精确定量及其开展精细化人体暴露评估提供技术方法和基础参数。

Microplastics are well-known emerging contaminants and has raised global concerns over its wide distribution in the aquatic environment. As a brominated flame retardant (BFR) additive in plastics, tetrabromobisphenol A (TBBPA) is gradually desorpted during the process of plastic degradation and can resorbed to the plastics. Ingestion of TBBPA-contaminated plastics by biological organisms can act as a vector transferring TBBPA to the food web, increasing risk throughout the marine food web, including humans. However, the exact bioavailability and human exposure of TBBPA sorbed to plastic debris is still not characterized. In this project, the quantitative analysis method of TBBPA sorbed to microplastics will be developed. The co-exposure system of microplastic and TBBPAs are being established to investgate the impact of microplastics on the uptake and accumulation of TBBPA in edible shellfish. An in vitro gastrointestinal model combined with in vivo mouse model will be used to detect the effects of microplastics on the bioaccessibility and bioavailability of TBBPA in edible shellfish. This proposed research will provide the technical methods to accurate analysis of environmental pollution, and the basic parameters of human exposure assessment of TBBPA sorbed to plastics.