自噬是发生在真核生物内高度保守的降解系统，由一系列自噬相关蛋白装配，深度参与诸多生物学过程并能够直接影响免疫应答，是宿主抵抗病毒感染的强大武器。自噬是高度动态的过程，能够及时感知细胞内的压力，并迅速做出反应以应对多种胁迫，因此，如何适时适度地启动并及时终止自噬对维持能量平衡和免疫应答至关重要。我们前期的研究揭示泛素化在自噬的起始及选择性底物识别过程中都发挥关键作用，并介导自噬与抗病毒免疫的交互反应。最近，我们的研究发现m6A RNA化学修饰参与自噬的调节（Cell Res 2018）并能够介导机体抗病毒免疫应答。本项目将深入研究自噬关键基因的动态m6A修饰及m6A作用相关蛋白在自噬及抗病毒免疫中的功能，绘制不同模式下m6A多层次调控自噬的修饰谱，揭示m6A介导自噬与抗病毒免疫的交互反应模型。这项工作将丰富现有的自噬调控理论，为改善困扰人类身心健康的多种疾病的治疗提供新的见解和理论依据。

Autophagy is a highly conserved degradation system in eukaryotes. It is orchestrated by a series of autophagy-related proteins, which are deeply involved in many biological processes and able to directly affect the immune responses. It is a powerful tool that the host use to defend against viral infection. Autophagy is a highly dynamic process that can instantly sense intracellular stress and respond quickly to a variety of stresses. Therefore, how to initiate and terminate autophagy in a timely and appropriate manner is crucial to maintain energy balance and immune response. Our previous studies revealed that ubiquitination plays an important role in the initiation of autophagy and selective recognition of substrate, and mediates the crosstalk between autophagy and antiviral immunity. Recently, our study found that m6A RNA modification is involved in the regulation of autophagy and can mediate the antiviral immune response. Here, we will explore the dynamic m6A modification and the fates of key autophagy genes, perform an in-depth study on the functions of m6A modifier in autophagy and antiviral immunity, draw the multi-level modification spectrum of m6A regulating autophagy in different models, and reveal the crosstalk between m6A-mediated autophagy and antiviral immunity. This work will enrich the theories of autophagy, and provide new insight and theoretical basis for the improvement of the treatment of various diseases that plague human physical and mental health.