骨创伤、肿瘤切除、骨不连、感染等原因导致的骨缺损日益增多，但目前临床常用的各种骨替代修复材料仍存在着供体有限、潜在免疫排斥和疾病传播、生物活性不足及可能诱发细菌性感染等缺陷。因此，骨科临床治疗对可激活病损骨组织再生修复的生物活性材料需求迫切。本申请提出，基于生物相容性好、降解速率和亲疏水性可调控的脂肪族聚酯，结合表面改性、生物矿化、多生长因子共包埋和顺时控释释放、抑菌抗炎成分引入等多种手段，开展具有诱导成骨促血管并具抗感染功能的可注射微球的制备和体内外生物学评价研究，在阐明该多功能生物活性修复材料与骨再生机制间的定性定量关联基础上，获得一类能够更为有效地促进骨缺损区结构恢复及功能重建的植/介入材料。近年，骨科微创技术及辅助器械发展迅速，为实现材料介入途径和治疗方案的优化提供了可能。本申请的可注射骨缺损再生修复材料，符合临床治疗所提倡的创伤小、手术耗时短、患者恢复快的术式需求，应用前景广阔。

Demands for bone repairing grafts or materials increase continuously in recent years due to numerous bone defects caused by trauma, tumor and aging, etc.. However, bone repairing remains a big challenge in clinical therapy due to the lack of ideal repairing materials. Traditional bone substitute materials, such as autologous, allologous and heterologous bone grafts, as well as artificial materials, present more or less disadvantages in respect to issues like shortage of donor, secondary surgery, potential immunological rejection and disease transmission, insufficient bioactivity, danger of infection, and so on. Therefore, there is a great and urgent demand for new kinds of bioactive materials that are able to induce and promote bone regeneration. To this end, a kind of multi-functional microspheres made from biodegradable polyesters is proposed as injectable bioactive materials for the purpose to induce bone regeneration. In this project, polylactide-based polymers and copolymers are chosen to prepare the injectable microspheres because they are FDA-approved biomaterials for in vivo applications. These polymers demonstrate flexibility in degradation rate, hydrophilicity/hydrophobility and cell affinity. Besides, other techniques, including surface modification, biomineralization, microencapsulation and time-dependent release of growth factors, and loading of antibacterial and/or antiinfective components, are applicable on these polyester microspheres. In an ideal situation, an injectable bone repairing material can be highly expected, which is able to recruit cells to the defect area to induce bone regeneration via sustained release of proper growth factors when they are injected into the area. This kind of injectable microsphere-based bioactive bone regeneration material is envisioned to have promising application clinically in accordance with the concept of minimal invasive surgery. Basing on in vitro and in vivo evaluations, moreover, qualitative and quantitative correlations between material designs and their osteogenic capacities will be statistically analyzed, which can be a valuable guidance for the design of other bone regeneration materials.