基于稳定金属有机骨架的光调控多元高效气相色谱分离新方法

金属有机骨架（MOFs）是一类具有高比表面积、可调控孔道结构性质的无机固体材料。新颖MOFs作为分离介质是气相色谱固定相研究的前沿课题。基于环境刺激引发MOFs孔道结构性质变化的研究刚刚起步，急需发展以稳定MOFs为主体的光调控材料，并探索其在新颖气相色谱分离方法中的创新应用。本申请书立足MOFs领域研究的前沿进展，提出了构建基于光调控的稳定MOFs作为气相色谱固定相的构想。在光调控下MOFs在孔道尺寸、形状、极性、表面基团等发生变化，形成可控的不同种类的色谱固定相，用于完成多元化的色谱分离任务。此基础科学问题的研究和解决，有助于我国研发具有自主知识产权的新型气相色谱固定相和新型气相色谱仪。

Metal-Organic Frameworks (MOFs) with high surface area, tunable pore structure and properties are hot materials in inorganic chemistry. Utilization of MOFs as stationary phases in gas chromatography arises analysts' attentions and becomes one of the frontier topics. Stimulus-response properties in MOFs is recently discovered in unstable MOF systems. Stable MOFs with photoactive group is of great importance to gas chromatographic applications as potential dual stationary phases under UV irradiation. Based on the recent progress in MOF chemistry, we propose the design of stable photoactive MOFs as dual stationary phases for gas chromatographic separation of isomers. The potential mechanisms include light-driven transformation of structures, polarities, sizes, and functional groups. This application will support the innovations of gas chromatography and stationary phases in China.