结肠纤维化是溃疡性结肠炎恶变的危险因素之一。湿生扁蕾有清热解毒，燥湿止泻之功效，我们的前期研究已证实，湿生扁蕾结肠靶向给药可使药物以较高浓度分散于结肠，能明显改善溃疡性结肠炎结肠充血水肿，促进溃疡愈合，对抑制肠纤维化也有明显作用，但其作用机理并不清楚。我们推测湿生扁蕾结肠靶向给药可能影响溃疡性结肠炎肠纤维化结肠组织细胞生长因子的分泌，并作用于CTGF/Smads信号转导途径，抑制结肠纤维化的发生、发展。为证实这一假说，我们以溃疡性结肠炎肠纤维化大鼠为研究对象，采用SP法、流式细胞术、RT-PCR、Western blot等技术，观察湿生扁蕾结肠靶向给药对溃疡性结肠炎肠纤维化大鼠结肠组织细胞生长因子分泌的影响及与相应细胞信号转导途径的关系，以期阐明湿生扁蕾结肠靶向给药抗溃疡性结肠炎肠纤维化的分子作用机制及科学内涵，为临床防治溃疡性结肠炎提供新思路和新方法。

Colon fibrosis is one of risk factors for UC malignant transformation. Gentianopsis paludosa has the effect of clearing heat , removing toxins, eliminating dampness and diarrhea. Pre-research have confirmed that Gentianopsis paludosa colon-targeted drug can make the drugs to a high concentration dispersion in the colon, and can improve ulcerative colitis colon congestion edema, promote ulcer healing, it has obvious effect to control the intestinal fibrosis, the mechanism of which is not clear. We presume that Gentianopsis paludosa colon-targeted drug may affect the secretion of UC colon fibrosis colon tissue cell growth factor, impact the CTGF/Smads signal transduction pathways, and inhibit the occurrence, development of colon fibrosis. To test this hypothesis, we use ulcerative colitis intestinal fibrosis rats as the research object. We adopt SP method, RT - PCR, flow cytometry, Western blot technology, then observe the effect about the secretion of Gentianopsis paludosa colon-targeted drug ulcerative colitis intestinal fibrosis rats colon tissue cell growth factor and the relationship of the corresponding cell signal transduction pathways. We expect to clarify Gentianopsis paludosa colon-targeted drug resistance to ulcerative colitis intestinal fibrosis the molecular action mechanism and scientific connotation, which can provide new ways of thinking and new methods for clinical prevention and control of ulcerative colitis.