组织器官衰老及其向退行性演变的全身分子显像是影像学研究的难点和重要发展方向。本项目在前期研究氨基酸代谢显像和细胞凋亡显像基础上，针对衰老致退行性演变组织器官涉及的氧化应激、细胞凋亡和代谢功能障碍机制及其标志物，构建合成靶向兴奋性氨基酸载体1(EAAC1)和胱氨酸/谷氨酸反向转运蛋白(XC-) 18F标记谷氨酸类似物、靶向磷脂酰乙醇胺(PE) 18F标记Duramycin类似物以及葡萄糖代谢示踪剂；建立D-半乳糖致衰老动物模型，联用多种示踪剂实现衰老致退行性变化组织器官氧化应激、细胞凋亡和葡萄糖代谢在体可视化全身动态PET显像，研究多种示踪剂摄取多参数与衰老标志物的相关性研究。本项目的完成可为衰老致退行性变化组织器官提供氧化应激、细胞凋亡和糖代谢多种示踪剂全身PET显像新技术，其转化应用可解决衰老致退行性演变组织器官全身分子显像的难题，为疾病诊疗和生物学功能显像提供新技术。

Whole-body molecular imaging of aging degenerative tissues and organs is difficulties and important development directions of medical imaging research. Based on the previous studies of amino acid metabolism imaging and cell apoptosis imaging, construction and synthesis of dual-targeting excitatory amino acids vector 1 (EAAC1) and cystine/glutamate reverse transporter (XC-) 18F labelled glutamate analogues, phosphatidylethanolamine (PE)-targeting 18F labeled duramycin analogues, and glucose metabolic tracer are performed according to mechanisms and biomarkers of aging degenerative diseases involvement in oxidative stress, apoptosis and metabolic dysfunction. Establishment of D-galactose induced aging models, in vivo visualized whole-body dynamic PET imaging of aging degenerative tissues and organs related to oxidative stress, apoptosis and glucose metabolism was done by combination of multiple tracers. Also, the correlation between multi-parameters of multi-tracer uptake and aging biomarkers was investigated. Completion of this project can provide multi-tracer whole body PET imaging new techniques for aging degenerative tissues and organs related to oxidative stress, apoptosis and glucose metabolism. Its translation and application can solve the problem of whole-body molecular imaging of aging degenerative diseases and provide new technologies for disease diagnosis and treatment and biological function imaging.