本项目基于临床术后遗留的组织生理结构缺损、易诱发感染、病灶复发等现状，针对个性化功能性仿生软组织研究的稀缺和瓶颈，提出构建具有药物缓释功能的仿生软组织替代物，对拓扑结构设计、3D打印制造和药动缓释模型之间的系统性科学问题展开研究。以心脏瓣膜、肛门、宫颈的临床数据为基础，进行病损组织个性化仿生重构；通过具有多级孔道结构分布的拓扑体设计，实现仿生软组织替代物中药物的缓释控制；通过生物材料体系的研究及3D打印，实现仿生重构体的快速制造；通过材料性能的优化、梯度多孔结构内药物释放控速机理研究，最终建立仿生软组织替代物的药物缓释模型。本项目构建的载药仿生软组织替代物，将通过个性化组织修复及药物缓释，同步解决病损结构的重塑和对原位组织功能性的持续修复两方面问题，为未来病损组织重建的临床治疗新策略提供理论指导，具有广阔的应用前景。

Due to the current postoperative issues of physiological structure defect, infection and recurrence of diseases, and the lack of personalized functional soft tissue substitutes, we herein propose the construction of biomimetic soft tissue substitutes with drug sustained-release function. In this project, the scientific problems among topological structure design, 3D printing and drug sustained-release model will be systematically studied. We will focus on the reconstruction of biomimetic cardiac valves, anus and cervix uteri based on the individual clinical data. The drug sustained-release in biomimetic soft tissue constructs will be controlled by gradient porous structure design, of which the rapid manufacture will be achieved through the study of biomaterial and 3D printing. Finally the drug sustained-release model of biomimetic soft tissue substitutes will be established via the optimization of material properties and the study on the mechanism of drug release control in the gradient porous structure. The drug-released biomimetic soft tissue substitutes constructed by this project could simultaneously solve the core issues of physiological structural repair and functional rehabilitation. It provides a new clinical treatment strategy for the reconstruction of defect tissues in the future, and has a broad application prospect.