可视化检测对大众日常监测食品卫生、饮水安全、空气质量等具有重要意义，但复杂环境中多元化学组分的可视化现场即时检测目前仍是个挑战。具有多重检测模式或原理的“多功能集成”是解决这一难题的有效思路，也是未来智能响应材料的发展趋势。本课题中，纤维素作为自然界最丰富的天然高分子，因其富含羟基的“多价性”拓扑结构，是制备多功能集成材料理想的分子结构设计与材料加工平台。按照模块化设计原理与组合化学的策略，精确合成发光、变色、富集、交联等多功能集成的纤维素基荧光材料，并利用纤维素基功能材料优异的加工成型性与可生物降解性，将优选的高灵敏、高选择性多功能纤维素材料转化成实用的、可抛弃、便携式、可视化的检测介质或器件，并重点探索其对复杂多元组分（如水中多元重金属离子或常见果蔬残留农药）的可视化现场检测或实时监测，有望获得具有应用前景的可视化多元检测材料与实用性技术，从而拓展纤维素的应用领域。

Visual detection is a highly practical approach for the public to supervise the safety and quality of food, water and air in daily life. However, it is still a challenge to realize on-site and real-time visual detection of the multiplex chemicals in real environment. Multifunctional modular integration of multiplex detection mode based on different principles is a possible solution, which is also a general trend of the smart responsive materials in the future. As the most abundant natural polymer on earth, cellulose is an ideal platform for molecular design and materials process to realize multifunction integration owing to its topologically multivalent structure of plentiful reactive hydroxyls. Herein, a series of multifunctional cellulose derivatives containing different responsive groups (e.g., luminescent, photochromic, enriching and cross-linking etc.) will be rapidly synthesized and screened via the strategies of modular design and combinatorial cellulose chemistry. The selected cellulose derivatives with superior sensitivity and selectivity will be fabricated into the disposable and portable materials or devices for visual detection of the typical heavy metal ions in water or the common residual pesticides on fruit and vegetables. Prospectively, on-site detection or real-time monitoring of multiplex chemicals such as heavy metal ions and residual pesticides would be achieved by the multifunctional cellulose-based fluorescent materials in this project.