已有多项证据表明默认网络与情感和记忆神经环路均有着一定程度的重叠与交互作用，因此默认网络是同时研究情感和记忆神经环路的一个重要的切入点和可能的突破口。然而默认网络的遗传机制及与情感和记忆神经环路的交互作用尚不明确。本项目拟围绕以下三个关键科学问题“（1）默认网络功能连接的结构基础是什么？（2）如何考察默认网路与情感和记忆神经环路的交互作用？（3）情感和记忆多个关键候选基因如何对默认网络进行调控？这种调控模式是否稳定存在？”，通过引入默认网络作为影像学内表型，试图探寻情感和记忆相关的关键基因对于默认网络结构连接和功能连接的影响，以及与情感和记忆神经环路的交互作用，为理解情感和记忆神经环路开辟新的研究思路。这一基于多模态磁共振影像的默认网络影像遗传学研究策略，通过集成不同水平的数据信息，可能从一个全新的角度部分揭示情感和记忆神经环路的发生发展机制，为本重大研究计划作出应有的贡献。

Convergent evidences have demonstrated that the default mode network (DMN) partially overlapped and intensely interated with the network of emotion and memory. Thus, default mode network may be a vital breakthrough point for studying the emotion and memory network. However, the genetic mechanisms of DMN and its relationships with emotion and memory network keep unclear. The current project will focus on the three key scienctific questions: (1) What is the anatomical bases of DMN functional connectivity?(2)How to investigate the interactions between DMN and emotion and memory network?(3) How the emotion and memory related genes modulate the DMN and the modualtion relationships keep stable?. By introducing the DMN as the intermediate phenotypes, this project attempt to investigate the key genes of emotion and memory affact the DMN anatomical connectivity and functional connectivity, and also the interations with emotion and memory networks. By the new study strategy of DMN imaging genetics based on multimodal imaging data, this project can integrate multi-level information, may illucidate the mechanisms of emotion and memory networks from a new perspective.