精神分裂症是一种常见的重性精神疾病，影响全世界近1%的人口，然而，长期以来，对精神分裂症的预防、诊断和治疗受制于对其致病原因和病理机制的了解不足。本项目拟围绕着精神分裂症的皮层发育异常机制研究，基于全新精细脑图谱，结合多模态磁共振影像，在更加精细的脑区亚区尺度上解析神经环路，研究精神分裂症的皮层亚区的异常形态和异常连接模式；利用双生子模型与全基因组数据，探寻遗传因素在皮层发育过程中的效应；在此基础上，基于影像遗传学策略研究精神分裂症相关的遗传学改变和基因表达如何引起特定皮层亚区形态及连接的改变。这一基于全新精细脑图谱，突破传统研究使用粗糙脑图谱的局限，利用多模态磁共振影像数据及多水平信息融合的研究思路，将为理解精神分裂症的病理机制开辟新的途径，从而为精神分裂症的异常脑机制研究提供更为全面的认识和可靠证据。

Schizophrenia is one of severe psychiatric disorders, affecting nearly 1% of the world's population. However, for a long time, the prevention, diagnosis and treatment of schizophrenia have been limited by the lack of understanding of pathogenic and pathologic mechanisms. Based on the new fine brain atlas, combined with multimodal magnetic resonance imaging, the project is to analyze the neural mechanisms on the more detailed brain sub-region, and study the cortical deficits of schizophrenia. And the genomic data were used to explore the genetic effects in the process of cortical development. Based on the imaging genetics strategy and gene expression data, this project investigates the genetic variations of schizophrenia affect cortical morphology and connectivity. Based on the new fine brain atlas, this project is breaking the traditional research limitations using rough brain atlas, the use of multi-mode magnetic resonance imaging data and multi-level information fusion research ideas, will help to understand the schizophrenia pathology mechanism and to open up new ways, thus to provide a more comprehensive understanding and reliable evidence for the study of abnormal brain mechanisms of schizophrenia.