急性甲亢肌病（ATM）是甲亢较少见的严重并发症，存在不同程度的脑水肿或脑出血，表现为急性延髓麻痹，尤以饮水呛咳、吞咽困难最常见，提示大脑功能或结构变化，但相关影像学表现尚不明确。本课题组的前期研究发现，以吞咽困难为主要症状的ATM患者静息态功能磁共振（FMRI）图像显示中央前回、中央后回、扣带回等脑区ALFF及FC强度下降， 推测该脑区功能活动异常可能参与发病机制。本课题拟在人群研究、动物层次，对静息态FMRI图像进行ALFF、FC、Reho分析，研究大脑功能区变化对ATM症状的影响，同时应用蛋白质组学整合研究策略，筛选并验证甲亢大鼠伴吞咽困难的脑组织的差异蛋白，为进一步早期预防诊断ATM提供新的理论依据和实验基础。

Acute thyrotoxic myopathy (ATM) is a rare but serious complication of hyperthyroidism. It includes different degrees of encephaledema or cerebral hemorrhage with obscure pathogenesis, presenting as abrupt onset of bulbar palsy with neurologic manifestations, especially choking in drinking water and swallowing, showing that brain function or structure has changed. However, its radiological examination findings is unclear. In the previous data of our group, we found that the resting-state FMRI images of ATM patients with swallowing difficulties as the main symptoms exhibited lower ALFF and decreased FC in precentral gyrus、central gyrus、cingulate gyrus and other brain regions, These findings are support of our hypothesis that abnormal functional activities in above regions may influence the pathogenesis of ATM. Therefore this study, we are focusing on the influence of cerebral activities on the ATM symptoms through analyzing the ALFF 、ReHo and FC in resting-state FMRI images in levels of molecule, tissue，organ and animal model. At the same time, we will combine application of proteomics to explore distinction of brain tissues in Hyperthyroidism rats with swallowing difficulties in protein. This research is important and valuable for further exploring the early diagnosis and prevention in ATM.