非粘液型肺腺癌的CT密度倍增时间研究及其在个体化随访中的应用

CT筛查确诊的早期肺癌生存获益远大于筛查过程中临床处置所带来的固有风险。胸部CT筛查在高危人群中的广泛应用导致肺部小结节检出率明显上升，目前我们面临的挑战是为筛查检出的亚临床难定性肺结节提供完善的随访策略和处理原则，最终提高肺癌诊疗的效价比。本研究拟针对表现为GGO的非粘液型肺腺癌进行研究，将自行设计开发的计算机三维密度定量分析软件（专利号：200810201670.4），运用于聚集扫描视野（FOV）、24pl/cm采像、1024矩阵、骨算法重建的超高分辨率序列，提高病灶的影像的空间分辨率和边界锐利度，分析肺部磨玻璃密度结节三维密度分布值、三维密度分布频率及总密度值变化值等定量指标，评价该原创性方法计算病灶密度倍增时间和随访磨玻璃密度影的价值，并与体积倍增时间对照，期望密度倍增时间为体积倍增时间提供有益的补充，为临床随访奠定基础，同时为个体化随访方案的制定提供新的思路。

For a worthwhile screening test, the mortality benefit of finding early stage lung cancer must outweigh the risk inherent in the clinical management of the screening process. Chest CT screening for high-risk individuals lead to high detection rate of small pulmonary nodules. Nowadays, difficulty in front of us is to provide an objective and quantitative method for follow-up and therapy for these sub-clinic ground glass opacities, and to improve potency ratio of pulmonary tumors. This study is to scan small focal pulmonary ground glass nodules with ultra-high resolution CT, technical core of which are field of view aggregation, 24pl/cm data collection, as well as 1024-matrix and bone algorithm reconstruction for analysis of three dimensional density diversity, three dimensional density disposition, three dimensional density curve as well as density change of ground glass nodules during follow-up examinations, and then we calculate density doubling time. Meanwhile, we measure volumes of the lesions and calculate volume doubling time. Their weights to the follow-up of non-mucinous pulmonary adenocarcinoma will be analysed.moreover, we provide a new idea for developing an individulized follow-up program.