二个具有逆转多药耐药功能的树脂糖苷的全合成及功能研究

糖链的可获得性一直是糖化学研究领域的热点和难点。本项目拟在合成具有重要生物活性的树脂糖苷Murucoidin V和Stoloniferin I的同时，发展一种以Pummerer重排反应为核心的新型糖基化反应。惰性的氧糖苷（Latent）通过一个简单的氧化就可能转化成所需要的糖基供体（Active），使得Pummerer反应在复杂寡糖合成中有很大的应用潜力。通过对树脂糖苷的化学生物学研究，进一步探寻其逆转多药耐药的作用机制，寻找可用于癌症辅助治疗的先导化合物。该项目的实施对快速构建复杂寡糖和发掘树脂糖苷潜在的药用价值具有重要的意义。

The availability of the complex oligosaccharide has been hot and difficult field of study of Carbohydrate Chemistry. The project is planned in the synthesis resin glycoside Murucoidin V and Stoloniferin I with important biological activity, and meanwhile the development of a new glycosylation reaction by using Pummerer rearrangement as the core reaction. Through the chemical biology studies of the resin glycosides , and further explore the reversal of multidrug resistance mechanism to find lead compounds for cancer adjuvant therapy. Implementation of the project is of great significance to quickly build complex oligosaccharides and to explore the potential medicinal value of resin glycoside.