面向生物分子相互作用分析的表面等离激元激光传感研究

研究和分析生物分子相互作用机理及分子结构与功能之间的关系，对我们在分子水平上了解生物体系至关重要，可有助于发现生命现象的本质，阐明生命活动的规律。过去常用的生物分子相互作用分析技术包括表面等离子体共振、生物膜层干涉、共振光栅波导等均存在着高灵敏度和高品质因子（FOM）无法兼顾的问题，极大地限制了其进一步发展与应用。本项目拟将表面等离激元与激光腔内传感技术结合，提出一种新型生物分子检测方法，通过深入研究表面等离激元激光局域电磁场增强特性，构建新型光子-表面等离激元高效耦合模型，开发具备大比例、强约束倏逝场的表面等离激元激光器，探索高性能生物分子传感机理和方法，预期实现高灵敏度（> 1.5 nm/nm）、高品质因子（FOM > 1/nm）、超小尺寸、超低样本需求量的生物分子传感，并完成对不同种类的生物分子间相互作用动态过程的原位、实时、在线检测，为高通量、高集成度的生物传感提供新的思路和方法。

To understand biological systems at the molecular level, it is very important for us to study and analyze the mechanism of biological molecular interaction and the relationship between molecular structure and function, which can help us discover the nature of life phenomena and clarify the laws of life activities. In the past, several biomolecular interaction analysis techniques have been widely used, including surface plasmon resonance, biofilm layer interference, resonance grating waveguide. However, one drawback of these techniques is that high sensitivity and high figure-of-merit can not be simultaneously achieved, which greatly limits their further development and applications. In this project, we propose a new biomolecular detection method by combining the technology of surface plasmon polaritons (SPP) and laser intracavity sensing. By studying the mechanism of enhanced light-matter interaction behind SPP lasing, designing new hybrid photon-plasmon structures, developing SPP lasers with large fraction of highly confined evanescent field, and exploring the high-performance sensing mechanism and methods, it is highly promising to realize a biosensor with high surface sensitivity (> 1.5 nm/nm), ultrahigh figure-of-merit (FOM > 1/nm), ultra-small size, and ultra-low sample size. In addition, in-situ, real-time and online monitoring of the dynamic interaction between different kinds of biomolecules can be also achieved. This project may provide a new way of technology and effective method for high-throughput and high-integration biosensing.