该项目计划利用柱芳烃类化合物在化学结构和手性构象上的特性，通过向柱芳烃的构成基元中引入侧链环，构建新型手性分子万向节。通过该项目的实施可望获得具有全新响应特性和能完成复杂功能的分子机器，并在以下几方面获得突破:.1.设计合成基于柱[6]芳烃和柱[7]芳烃的新型分子万向节，开发静态压力、光照和电化学驱动的具有特殊响应功能的手性分子机器。.2.借助分子万向节的in/out翻转平衡特性，创建能对多种不同外界刺激兼具响应效应的正交控制手性分子万向节，获得能实现复杂功能的手性分子机器。.3.探索合成带有多个柱芳烃基元和多个不同响应基团串联而成的多环手性分子万向节，构建可以多步控制和分阶段响应的新型手性分子机器。.4.深入研究大环柱芳烃的分子包结热动力学，利用柱芳烃分子万向节翻转过程中空腔打开和关闭切换的特点，开发具有对手性分子选择性捕获和释放功能的分子开关。

The project plans to construct a new type of chiral molecular universal joints by introducing a side-chain ring into one constituent unit of pill[n]arene, by virtue of the unique chemical structure and chiral conformation of pill[n]arene compounds. By performing the project, we expect to obtain molecular machines with unique response characteristics and complex functions and achieve breakthroughs in the following aspects:.1. We will design and synthesize new chiral molecular universal joint based on pill[6]arene or pill[7]arene, and develop chiral molecular machines with special response functions that can be driven by static pressure, light, or electrochemistry..2. By means of the in / out conformational conversion characteristics of the pill[n]arene-based molecular universal joints, we will discover chiral molecular universal joints that can be orthogonally driven by a variety of external stimuli and construct molecular machines that can accomplish complex functions..3. This project will explore the synthesis of chiral molecular universal joints comprising by multiple pill[n]arene units and various response groups, and construct a new type of molecular machine that can be stepwise controlled..4. This project will conduct an in-depth study of the thermodynamics of the pill[n]arene-based molecular universal joints, and exploit the switching of cavity empty and occupation caused by the flipping of ring units, to develop enantioselective capture and release of chiral guest molecules.