该项目设计合成多种柱芳烃衍生物，并以其为超分子主体分子包结光化学反应底物，通过光直接激发或光敏化的方法在柱芳烃空腔中诱导不对称光化学反应。利用柱芳烃类化合物在化学结构上、构象上以及对紫外光吸收上的特有性质，建立新型超分子手性诱导策略。通过该项目的实施可望实现光化学反应的高效手性诱导和立体选择性可控的目标，并在以下几方面获得突破:1.合成具有对光反应底物有强包结能力的非手性柱芳烃，以圆偏振光为光源，验证尚未见诸报导的分子间绝对不对称合成和绝对不对称敏化。2.设计合成并拆分出具有面不对称性质的手性柱芳烃衍生物，并以其为手性源完成对多个不同类型光化学反应的手性诱导。3.将柱芳烃和其他手性超分子主体分子进行连接，合成“杂化”主体分子，利用多部位协同包结作用提高手性光化学反应的选择性。4.该研究拟通过优化反应条件，调整主体分子结构、溶剂、压力、温度以及激发波长等来获得高的光化学反应效率和立体选择性。

This project will focus on the design and synthesis of a variety of pillar[n]arene derivatives, and use them as supramolecular hosts for conducting asymmetric photochemical reactions by direct photoexcitation or photosensitization. By virtue of the unique chemical structure, conformation and UV absorption properties of pillar[n]arene derivatives, this project aims to construct novel supramolecular photochirogenesis strategy. It has the potential to overcome the shortcomings of chiral photochemistry: the low efficiency on chiral induction and chirality control. By performing the project, we expect to realize excellent stereochemical control in chiral photoreaction as well as the following breakthrough:.1..Preparing non-chiral pillar[n]arene derivatives with strong binding capacity for photosubstrates. By using circular polarized light as light source, we will directly photo-excite or sensitize photosubstrates included in the cavities of pillar[n]arene derivatives to realize intermolecular absolute asymmetric synthesis or absolute chiral photosensitization..2..Planar chiral pillar[n]arene derivatives will be designed and synthesized. The corresponding enantiomers will be separated and used as chiral hosts for mediating different kind of chiral photoreactions..3..This work will also conjugate the inherent chiral hosts with pillar[n]arene to give a novel kind of “hybrid” chiral hosts. We will try to improve the stereoselectivity of chiral photoreactions by taking advantage of the multiple synergetic binding interactions from cyclodextrin-pillar[n]arene conjugates..4..With the pillar[n]arene derivatives as chiral inductors, we will manipulate the reaction factors, such as temperature, solvent, pressure and irradiation wavelength to achieve optimized stereoselectivity.