阐释中药及其组分配伍的协同增效机制是揭示中药配伍科学内涵、优化中药组方的关键。如何定量表征不同中药引发的靶点群之间相互协调，促进新作用机制的“涌现”，是系统阐明协同配伍机制必须要解答的问题，也是其瓶颈所在。目前对该机制的研究多集中在靶点实体（靶点群、模块、通路等），尚未开展对靶点群 (模块)间关系的研究。课题组前期提出了模块间协调差异的定性判别模型（IMCC）。在此基础上，本研究以熊胆酸、栀子苷干预脑缺血为示例，通过融合拓扑参数、统计筛选、功能优化建立模块间关系定量分析模型，对单一组分和配伍组的药物应答模块间关系进行定量、对比整合、相关性分析，进而识别协同增效的靶点模块间协调关系及其涌现和保守的内在机理，并采用大鼠大脑中动脉阻断模型进行生物学验证，从模块间协调关系角度揭示熊胆酸和栀子苷协同增效机制，为阐明中药配伍协同增效的“系统整合式”的作用机制提供新方法，为中药组方的深度解析提供新思路。

Elucidating the synergistic mechanism of Chinese herbal medicines (CHMs) and their components is the key to reveal the scientific connotation of CHMs compatibility, as well as to optimize prescriptions. How to quantitatively characterize the coordination between target community of distinct CHMs for new action “emergence”, is the essential procedure, as well as the bottleneck, for systematically elucidating the synergistic mechanism of CHMs. However, researches on this topic mainly focus on the target entity, such as target communities, modules and pathways, the targeted inter-module coordination related to synergism is far from clear. In our previous study, IMCC score was constructed to qualitatively detect the diversity of inter-module coordination. Base on the IMCC, here, we integrate the topological parameters, statistical analysis, and functional fitting screening to construct a quantitative model for inter-module coordination, using the ursodeoxycholic acid (UA) and jasminoidin (JA) treating cerebral ischemia as demonstration subjects. Subsequently, the quantitative analysis, comparative integration and correlation analysis are conducted on the drug-specific inter-module coordination, to identify the coordination between target modules related to synergism, and to investigate the internal mechanism of subsequent integration emergence and conservation. Finally, the potential synergistic mechanism of UA and JA from the perspective of inter-module coordination will be validated by biological experiments using the model of middle cerebral artery occlusion in rats. This study will provide a novel method for clarifying the “systematic integration” mechanism of synergistic compatibility of CHMs, and provide a new perspective for prescription analysis.