脑深部电刺激（DBS）对中晚期帕金森病临床症状的改善效果显著。制约DBS术推广应用的主要原因之一是手术技术门槛，其中电极植入靶点的误差精度是核心和关键问题。目前国内外缺少针对DBS手术误差的系统性科学研究。本团队前期通过DBS术诸多环节中的一个环节（标记点注册）进行探索创新，明显减小了电极植入靶点误差，而其它环节的误差影响和误差数据尚不清楚。因此，有必要对DBS术全过程误差进行系统研究，从而将DBS术的误差控制由术者的个人经验问题提升为具有共性研究价值的科学问题。本课题拟系统研究DBS手术全过程、全要素误差，通过数学建模量化分析方法，明确误差因素、误差分布、误差传递、误差控制等数据，探索误差数据规律，解决误差分析、控制、验证等误差未知科学问题，提出DBS误差控制的改进措施，为指导更精准的DBS手术提供基础数据与理论依据。预期研究成果对DBS术在国内外的临床推广和手术疗效最大化具有重要意义。

Deep brain stimulation (DBS) can improve the clinical symptoms of Parkinson's disease obviously. One of the main reasons restricting the application of DBS is the technical difficulty of surgery, in which the electrode implantation error is the core and the key issue. Currently, there is a lack of systematic scientific research on DBS surgical errors in the world. Focusing on one of multiple steps of DBS surgery, registration of markers, our team explored innovative registration methods to reduce the electrode implantation error obviously. However, the basic error data and its influence in other DBS steps were not clear. Therefore, it is necessary to study the error of the whole process of DBS systematically so as to elevate the error control of DBS from the personal experience of neurosurgeon to a scientific problem with common research value. This project plans to study all the factor errors in the whole process of the DBS surgery systematically. Through the mathematical modeling and quantitative analysis methods, we aims to identify all the error data, including error factors, error distribution, error propagation, and error control. Basing on these data, the error characteristics will be explored. And the key scientific issues of error analysis, error control and error verification will be resolved. This study provides the basic data and theoretical basis for guiding more accurate DBS surgery. Expected results of the study have a great significance for maximize the effectiveness and the clinical promotion of DBS.