益气、温阳药是治疗心衰的主要中药，我们从上一个国家自然科学基金资助项目的研究结果来看：益气、温阳药物能够改善心梗后心衰大鼠的心功能，然而温阳药物似乎并不能抑制血液及心肌局部RAAS的激活，但益气药物具有这一作用，且随着用药时间的延长，益气药物抑制RAAS的作用更明显，温阳药RAAS虽与模型组比较无统计学差异，但似乎随着用药时间的延长，温阳药也有抑制RAAS的趋势。那么温阳、益气药物更长时间的应用是否能够改善心功能，其更长时间的长期应用对RAAS系统的作用如何，以及如果温阳药物更长时间治疗能够继续改善心功能，但不能证明其能够抑制RAAS的激活，那么温阳药物长期应用改善心功能的机制是什么？这些问题均为上一个课题未能解决的方面。本研究进一步探讨温阳、益气两类药物更长时间应用不同用药时间点时对慢性心衰大鼠RAAS、细胞因子、心功能和心室重构的作用差异，为临床长期应用温阳、益气药治疗慢性心衰提供依据

The Qi, Onyang drugs is a major traditional Chinese medicine for the treatment of heart failure, we look at the results from research on a National Natural Science Foundation-funded project: the Qi, Onyang drugs can improve heart function in rats with heart failure after myocardial infarction, howeverthe Onyang drugs does not seem to inhibit the activation of the blood and myocardial RAAS, but Qi drugs with this role, and with the time extension Qi medication drugs inhibit the role of RAAS, Onyang medicine RAAS with the model groupno statistically significant difference, but it seems to extend the time with the medication, Onyang drugs inhibit the RAAS. Yang, Qi drug longer application can improve heart function, the longer the long-term application of the role of the RAAS system, and if the the Onyang drugs longer treatment can continue to improve heart function, but can not demonstrate ability to inhibit the activation of the RAAS, then what is the the Onyang drugs long-term application of the mechanism to improve heart function? These problems are on the unresolved aspects of a topic. This study further explores the yang, Qi and two types of drugs longer apply different treatment time points for clinical long-term application yang, Qi drug treatment of chronic heart failure in rats RAAS, cardiac function and ventricular remodeling differences chronic heart failure, providing experimental evidence.