慢性肾功能不全者（CRF）50%死于心血管并发症(病理性心脏重塑)，目前尚缺乏有效防治手段。申请者已完成的国家自然基金项目，在阐明中药肾心宁方可通过拮抗RASS从而改善CRF心脏重塑机制的同时，发现：AT-Ⅱ受体1敲除小鼠（AT1KO）心脏能量代谢存在明显紊乱，而CRF治疗所遵循的低蛋白饮食有可能在片面保护肾功能的同时会加重心脏能量代谢失衡。温阳补气中药纠正能量代谢的功效与CRF心肾阳虚的临床表现相当一致。结合中医"心肾阳气互资"理论，本课题进一步提出"肾心宁方亦可通过调节心脏能量代谢失衡改善CRF病理性心脏重塑"的假说。拟通过不同心脏重塑模型（CRF模型及慢性心功能不全模型），在不同饮食条件下(正常饮食，低蛋白饮食)，运用肾心宁方及拆方（益气温阳、活血泄浊）干预，着重比较研究脂肪酸和葡萄糖代谢失衡机理途径的变化，以期阐明中药肾心宁方改善CRF心脏重塑能量代谢紊乱的机制及其中医理论意义。

There are 50% of the patients with Chronic renal insufficiency ( CRF) died of cardiovascular complications (pathological cardiac remodeling) , for which there is no effective prevention and treatment. The applicant has completed an research subject supported by the National Natural Science Foundation , the Mechanism study on heart remolding of chronic renal failure mice with Angiotensin II Type 1a Receptor knock out and therapeutic effect of herbal formula Shenxinning . In the study, we found that, by antagonizing the RASS , the herbal formula can reduce uremic toxins and then improve the cardiac remodeling. We also found that the heart energy metabolism in AT1KO + CRF mice was obvious disorders and it was more serious in the CRF mice with strict low-protein diet. According to the theory of mutual promotion of the heart and kidney yang,we put forward the hypothesis that Shenxinning can improve the pathological cardiac remodeling by regulating the energy metabolism.In this study, with different cardiac remodeling model (CRF model and chronic heart failure model ) and under different dietary conditions ( normal diet, a low protein diet ) , we intend to use Shenxinning and its component( replenishing qi and warming yang, promoting blood circulation to purge turbidity ) to carry out a comparative study on the changes in the pathway of fatty acid and glucose metabolism in order to clarify the mechanism of improving energy metabolism disorders of CRF cardiac remodeling mice by Shenxinning and to explain its TCM theoretical significance.