近几年，可见光和过渡金属协同催化领域作为一个新的交叉研究领域受到人们的重视，其中最常见的过渡金属有镍、钴、钯等。尽管金属铜具有廉价易得、低毒、反应化学丰富等优点，但是由于它在激发态的寿命短，三价铜的稳定性差，且二价到三价的能垒高等因素，使得如何实现铜和可见光协同催化面临着巨大挑战。该领域的现有研究主要集中在较为简单的单组分反应及两组分之间的直接偶联等，而对较复杂的反应体系，如三组分反应体系仍然缺乏研究。本课题将集中研究从简单易得的原料出发，利用铜和可见光协同催化的策略，开发在常规条件下难以实现的三组分选择性成键反应。申请人将结合前期工作，通过合成新型光催化剂和开发新的协同催化策略等方法，实现碳氢键、碳碳键在室温条件下的选择性断裂及多样化转化，进而发展出一系列高效的碳碳键、碳杂原子键的选择性成键反应，为有机合成提供高效、高选择性的合成方法。

Over the past years, the merger of transition-metal catalysis and visible-light catalysis is emerging as a powerful tool for the rapid construction of valuable chemical bonds from simple starting materials. The commonly employed transition metal in this cooperative catalysis mode includes nickel, cobalt, and palladium. Copper-catalyzed transformations have gained great attention due to the abundance, low toxicity, and diverse reactivity of copper. However, the merger of copper with visible-light catalysis is still underdeveloped. This attributes to the following reasons: 1) short excitation time and instability of Cu(III), 2) high transition state energy to transform Cu(II) to Cu(III). The existing examples in this area are limited to one-component or two-component cross-coupling reactions. The reactions of merging copper and visible light in more sophisticated systems, such as three-component reaction remain a formidable challenge. This proposal is aimed to develop selective three-component reactions enabled by the merger of copper and photocatalysis, which are inaccessible under regular conditions, from easily available starting materials. The cooperative catalytic strategy will emphasize on developing new photocatalysts and new reaction modes, to achieve efficient transformations of C-H or C-C bond to other diverse chemical bonds with high levels of selectivity under mild conditions.