睡眠不足可通过饮食调节促进2型糖尿病（T2D）的发生，血糖波动是评价T2D患者血糖控制及疾病进展的重要指标。然而，睡眠不足是否可以通过饮食调节途径参与T2D患者的血糖波动目前尚不清楚。本课题拟对“睡眠不足通过饮食调节途径影响T2D患者的血糖波动”这一机制进行验证。本研究将包含两部分：第一部分采用纵向研究设计，对118名T2D患者的睡眠和动态血糖进行为期8天的实时监测。第二部分采用随机对照试验，对50名患者于睡眠中心模拟睡眠剥夺，进一步阐明睡眠不足如何通过饮食调节对T2D患者的血糖进行调控。干预期间，实验组给与部分睡眠剥夺（5小时睡眠），对照组保持正常睡眠（9小时睡眠）；同时，对睡眠、血糖、及饮食相关指标进行动态监测。睡眠是一个受个体支配的行为，最新的糖尿病管理指南建议将睡眠纳入综合健康评估中，然而充足睡眠的重要性仍未受到重视，本课题将为构建糖尿病的综合疾病管理模式提供新的方向和思路。

Sleep loss may increase the risk for type 2 diabetes (T2D) through its regulation on eating behaviors. In patients with T2D, glucose variability is an important indicator of disease control and progression. Nonetheless, the impact of sleep loss on glucose variability via eating behaviors remains unknown. The aim of this study was to investigate the effect of sleep loss on glucose variability and related mechanisms, particularly eating behaviors. This study will be conducted at two stages. During the first stage, a longitudinal design will be used and 118 adults with T2D will be recruited. Participants’ sleep and glucose will be monitored continuously over the course of 8 days. During the second stage, an experimental design will be used. A total of 50 adults with T2D will be randomized into two groups. The experimental group will maintain normal sleep duration (9h sleep) and the experimental group will receive partial sleep restriction (5h sleep). The intervention will be conducted at a sleep center where participants’ sleep, glucose, and parameters related to eating behaviors will be measured. Sleep is a health behavior that can be controlled and regulated by an individual. The most recent diabetes guideline by the American Diabetes Associated has recommended the inclusion of sleep assessment among patients with diabetes. Nonetheless, the importance of adequate sleep remains under-recognized. Findings from this study will provide novel directions and strategies for diabetes management.