交叉偶联反应是有机合成化学的基石，功能强大，应用广泛。交叉偶联反应现存的难点是烷基亲电试剂与亲核试剂的偶联。最常使用的烷基亲电试剂是烷基卤化物，但是因为烷基卤化物与金属催化剂氧化加成速度慢于beta-氢消除，使得卤化物消除卤化氢的副反应成为主导，这一特质造成了烷基亲电试剂交叉偶联反应发展缓慢的现状。我们将寻找合适的催化体系，通过对过氧酰化合物裂解过程及产生自由基的控制，把过氧酰这种古老的化合物转变为通用的新型烷基亲电试剂。探索过氧酰化合物的优越性，尝试超越烷基卤化物等现有亲电试剂已经完成的反应，挑战其还未实现的难点反应。探索过氧酰化合物与芳基乙烯、简单烯烃（孤立烯烃）、共轭二烯及炔烃的反应，实现温和洁净的Alkyl-Heck、Alkyl-Sonogashira等反应。

Halogen compound is the king ruling the cross coupling since the very beginning of this field. There is no doubt that it is most important type of chemicals. But there are some stubborn unsolved problems rise from the innate features of halogen compounds. For example, the facile beta-hydride elimination of alkyl-metal halogen intermediates generated in the cross coupling. We wish to develop the efficient catalytic systems which can convert alkyl diacyl peroxides, the very ancient type of compounds, to a general and useful reagents to address the challenges which halogen compounds cannot address (or address at a very high cost). We want to find the new complementary chemicals and apply this type of chemicals into alkylations of alkenes and alkynes. We have some initial results which can prove the possibilities of our proposal.