激光医疗技术因其精确度高、疗效良好及安全可靠等独特优势受到了广泛关注，考虑到水在激光与组织相互作用过程中的重要性，开展激光作用下液体的光响应特性及相关流体动力学过程研究十分必要。其中，光致空化现象及空蚀造成的机械损伤效应是激光与液体相互作用过程中必须考虑的关键问题，也是研究的难点问题。综合申请人的光学研究背景和课题组长期从事微流体研究的优势，本申请书首次提出“采用CO2红外激光作为激光辐照源，利用高速摄像技术结合红外热像探测技术，研究液体中光致空化现象的形成机理及相关流体动力学过程，并在此基础上通过引入激光模式控制技术和微纳结构实现对空化现象的主动调控和抑制”的创新性研究方案，开展物理机制、微观现象、调控技术等方面的基础研究，建立红外激光作用下光致空化现象完整可靠的物理图像，为实现精准控制激光治疗过程和治疗效果提供参考依据。

Laser medicine has been widely applied in medical diagnosis and treatment due to its unique advantages of high accuracy, effective treatment, and reliable safety. Since water plays an important role in the interaction between laser and tissues, it is essential to explore the liquid optical response and related fluid dynamics process, such as laser-induced cavitation, bubble collapse and the associated mechanical effects. However, generally the interaction between laser and liquid is extremely complicated arising from the fast dynamics process and many coupled phenomena. By combining the techniques of high speed photography and infrared thermal imaging, we are studying the formation mechanisms and fluid dynamics of laser (CO2 infrared laser) induced cavitation. Moreover, controllable manipulation of the cavitation in liquid is realized, such as by changing laser mode or introducing micro-structures (like nanoparticles or porous medium) in liquid. These results of physical mechanisms, dynamic processes and controllable techniques of the laser induced cavitation, can provide helpful guidance to improve the performance of laser impacting on tissue.