聚羟基脂肪酸酯（PHA）是一类可生物降解的多聚物，被认为是替代塑料的未来材料。为了降低PHA的生产成本，开发新型高产的生物资源并利用有机废水生产PHA是以可持续性方式解决这一问题的有效方法。嗜盐古菌Haloferax mediterranei是一类新型PHA积累微生物，其在代谢途径多样性、特殊PHA共聚物生产和产物回收等方面具有显著的优势。但是，其利用废水合成PHA产率低成为工业应用的瓶颈。本研究探索外源磁场强化H.mediterranei 合成PHA的生物机制与技术方法，以磁强化技术解决PHA产率低的问题。项目结合代谢工程研究磁诱导PHA合成及其磁效应等基础理论问题，建立以磁强化提高H.mediterranei合成PHA产率和增加PHA中长链单体组分含量的技术体系。研究在降低PHA成本及开发利用嗜盐古菌等方面具有重要意义。

Polyhydroxyalkanoates (PHA) is the biodegradation polymers materials, which is considered as potential substitutes for petrochemical-derived plastics. However, the main obstacle to wide application of PHAs is its high production cost. As the possible method, seeking the novel PHA producer with high productivity and utilizing the wastes as carbon for PHA production can reduce the production cost in a sustainable way. H. mediterranei is the best PHA producer because of its advantages of the easy PHA recovery, utilizing various wasted and recycled carbon, and special copolymers synthesis. The main obstacle to limit its large-scale application is the low PHA productivity while using the wastewater as the fermentation substrate. Therefore, it is necessary to take actions to enhance the activity and the storage of external carbon into PHA. For this purpose, this research will explore the enhancing approaches to increase PHA productivity by external magnetic field. The magnetic biological effects including of DNA coding and enzyme function will be explored to insight in the mechanism of external magnetic induction. This study is of significance to reduce PHA production cost by utilizing the halophilic achaea.