致痫区（epileptogenic zone）定位仍然是癫痫外科的难题之一。有创定位手段（颅内电极脑电图，icEEG）虽被视为“致痫区定位金标准”，但其仍具有局限性。无创评估手段具有无创性、便捷性、评估角度全面等优点，并且能够为颅内电极埋置方案提供指导，在本领域仍然占有重要地位。高密度脑电源定位（dESI）作为一种较新的无创评估手段，同时具备高时间和高空间分辨率，在目前已有的致痫区定位研究（基于公共头模）中已显示出良好的准确性。基于个体化解剖结构的个体头模（IHM）将进一步提升dESI的精准性，但相关技术实现具备一定的复杂性。本研究拟通过癫痫外科临床中的难治性癫痫病例，应用发作间期及发作期脑电数据，详尽探讨基于个体头模的dESI-IHM技术的方法学和可行性，利用包括“金标准”icEEG在内的多种标准，全面评价该技术的准确性并探讨该技术对癫痫外科手术的指导价值。

Localization of epileptogenic zone is one of the most challenging issues in territory of epilepsy surgery. Invasive localizing methods (intracranial EEG, icEEG) is deemed as the "gold standard of epileptogenic zone localization", but still have many limitations. Non-invasive methods are playing important roles in this territory since they have good features such as non-invasiveness, convenience, sufficient coverage, etc, and they can provide instructions to icEEG electrodes implantation strategies. As a newly emerged non-invasive evaluation method, dense array EEG source imaging (dESI) technique showed good accuracy in previous studies on epileptogenic zone localization, with atlas head models. Individualized head models (IHM) based on individualized anatomies can further raise the accuracy of this technique, but realization of such technique is sophisticated. This study is designed to discuss the methodology and feasibility of dESI technique based on IHM (dESI-IHM) in refractory epilepsy cases using interictal and ictal EEG data. Furthermore, this study aims to evaluate the accuracy and instructive value for icEEG implatation surgeries of this technique by multiple criteria including the "gold standard".