基于双光束频域OCT技术与脉搏波的眼底血管弹性成像及其在动脉硬化定量检测评估中的应用

小微血管的形态与弹性改变可更早期地预警、筛查动脉硬化及高血压、冠心病、中风等心脑血管风险事件。眼底血管是人体唯一直接可见的血管网络，是全身微循环的组成部分，检测、评估眼底血管形态与弹性，在预测、筛查和诊断心脑血管疾病方面具有重要的临床价值。但是，目前基于高速眼底摄影的眼底血管弹性检测方法存在信噪比低、可靠性差等诸多不足，导致脉搏波传播速度这一公认的重要指标的测量结果存在数量级差异，眼底动脉的弹性理论模型的研究也属于空白。.本课题将研究采用双光束光学相干层析成像技术，分析视网膜动脉血管脉动的脉搏波形，通过相位解析等信号处理方法获取脉搏波传播速度和动脉血管、血流脉动的动态信息以及血管形态尺寸，进而通过非线性半解析解法和有限元分析法，建立眼底血管弹性理论模型，为评估人体微循环、全身血管硬化程度以及预测、筛查和诊断高血压、中风、心梗、脑梗等心脑血管疾病提供理论与方法，具有重要的科学意义和应用前景。

The changes of the morphology and elasticity of arteriole and microcirculation can be used to predict and arteriosclerosis and cardio-cerebrovascular diseases at more early stage. Retinal vessels, as the part of the whole circulation, are the only direct accessible vasculature. Therefore, it has potentially great clinical applications in prediction, screening and diagnosis of cardio-cerebrovascular diseases to measure and evaluate retinal vascular morphology and elasticity. However, there is great controversy in detection of retinal vessel elasticity. The elastic theory of retinal vessel hasn’t been established..Based on previous research, in this proposed project, we aim to develop dual beam optical coherence tomography (OCT) to detect pulse wave of the retinal arteriole, and obtain pulse wave velocity, blood flow dynamics, and caliber based on phase and signal analysis. With the measured parameters, we aim to develop elastic theory of the retinal arteriole based on nonlinear semi-analytical solution and finite element analysis. The proposed research has both scientific values and clinical applications in evaluation of whole circulation and arteriosclerosis, as well as in prediction, screening, and diagnosis of cardio-cerebrovascular diseases, such as hypertension, stroke, myocardial infarction, cerebral infarction, diabetes.