目前激素抵抗型肾病综合征（SRNS）无特效疗法，现代治疗仅可使部分缓解，易进展为终末期肾病。课题组采用右归丸配合糖皮质激素治疗，疗效优于单纯使用激素治疗。认为SRNS激素耐药主要与肾阳虚有关，符合中医“益火之源，以消阴翳”的理论，中西医结合有治疗优势，但因部分中草药的肾毒性及复方制剂的复杂性，限制了补阳药在肾病中的应用。我们提出“淫羊藿苷联合激素干预SRNS提高疗效的机制与温阳药调节GR数量和GR亚型比例，调节足细胞SD2AP相关蛋白及自噬有关”的假说，病证结合，以下丘脑-垂体-肾上腺皮质轴功能为阳虚证指标，进行GC耐药与肾阳虚证相关性研究，采用QRT-PCR、WB、细胞免疫荧光、激光共聚焦、透射电镜等技术，在免疫方面检测GC-GR作用环节；在肾小球检测足细胞裂孔膜及相关蛋白表达、足细胞自噬体，阐明淫羊藿苷联合GC对SRNS的协同作用及分子机制，为中西医结合治疗SRNS寻找新途径。

There is no effective treatment for Nephrotic syndrome (NS), GCs are the mainstay of NS therapy,but even GC in combination with new immunosuppressants there are still some patients can not obtain clinical remission. The main mechanism of SRNS is considered about the damage to the GCs functional. However, the Chinese medicine considers that the GCs can cause the kidney-yang deficiency . In the research project, the rats of SRNS model were duplicated by Doxorubicin, and treated with GCs. At the different stages of GCs treatment, the compatibility of icariin (ICA) was used to supplement the kidney yang. The project aims to study the effects and mechanisms of the compatibility use of ICA and GCs, by observe the podocyte autophagy and expression of GR.Through HPA axis of SRNS model, to verify the source of "friendly fire to blow falls" theorys of Chinese medicine. Lay a theoretical support for clinical practice and develop a better Traditional Chinese Medicine for prevention and treatment of SRNS.