丘脑底核电刺激（STN DBS）是治疗帕金森病(PD)安全有效的新技术，但其机制及是否能延缓PD神经元进行性变性尚未明确。本课题组前期研究显示,STN DBS可以纠正PD患者异常运动环路的代谢模式，增加PD大鼠纹状体多巴胺(DA)合成酶的表达。提示该治疗调节大脑运动环路的兴奋性，并改善DA系统的功能。本课题拟通过FDG PET显像观察长期STN DBS对中期PD患者大脑运动环路特异性代谢模式的影响及应用18F-fluorodopa，11C-raclopride和11C-CFT PET显像检测STN DBS对中期PD患者大脑DA摄取率、DA受体和DA转运体代谢的影响，同时研究STN DBS对PD大鼠模型DA系统的调节和神经细胞再生的影响。本研究将为STN DBS治疗PD的最佳时机提供依据，并探索其对DA系统的调节以及是否可能延缓PD的进展。

Deep brain stimulation of the subthalamic nucleus (STN DBS) has become a safe and effective new tool for the treatment of Parkinson's disease (PD), however the precise mechanism and whether this intervention could postphone the progression of neurodegeneration of PD remain unclear. In previous studies, we found STN DBS rectified the PD-related covariance pattern (PDRP) of regional metabolism of PD patients using positron emission tomography (PET). The treatment also increased tyrosine hydroxylase expression in striatum of PD rats. These findings indicate STN DBS adjusts the activity of brain network and modifies the function of dopaminergic(DA) system. To uncover if STN DBS is neuroprotective and its influence on DA system, in this project, we investigate the effect of long term STN DBS to medium term PD patients on PDRP using FDG PET; in addition, we detect the effect of immediate STN DBS to PD patients on DA uptake rate,DA receptor and transportor metabolism. Meanwhile, we research the influence of STN DBS on DA system and neurogeneration in striatum and midbrain of PD rats. The study will explore the theoretical basis of STN DBS and benefit in revealing optimal time of STN DBS operation to PD patients.