Fe、Cu基纳米材料用于NIR-II荧光成像指导的光/热增强化学动力学治疗

本项目针对“化学动力学疗法”在抗癌治疗中存在肿瘤细胞低浓度H2O2难以支撑高效芬顿/类芬顿反应、药物安全性差及无法实时监控治疗进程等问题开展研究。拟通过Fe、Cu基光热材料、葡萄糖氧化酶和NIR-II区稀土发光材料之间的功能复合来解决上述问题。首先，利用葡萄糖氧化酶在肿瘤细胞内反应生成H2O2，提升内源H2O2浓度，再辅以光照触发Fe、Cu基材料光热效应，内源和外源刺激同时促进芬顿/类芬顿反应；其次，建立完善的药物安全评价体系，通过体内外毒性、体内分布及排泄、主要器官病理和血液生化指标等数据评估药物安全性；然后，利用稀土发光材料NIR-II荧光成像，提高组织穿透深度和分辨率，实时监控治疗过程。本项目的最终目标是构筑一类肿瘤微环境触发、NIR-II区荧光成像指导的高效光热/化学动力学协同治疗体系，并研究内源和外源刺激对“化学动力学疗法”的促进机制，为今后该类体系研究提供理论依据。

This project aims to develop highly efficient "Chemodynamic Therapy" in the anti-cancer treatment, to solve the problems including low concentration of H2O2 in tumor microenvironment, poor drug safety and the inability to monitor treatment progress in real time. For the reasons, it is planned to integrate Fe, Cu-based photothermal materials with glucose oxidase and NIR-II rare earth luminescent materials through functional recombination. First, glucose oxidase is used to generate H2O2 to increase the endogenous H2O2 concentration. And the photothermal effect of Fe and Cu-based materials is triggered by illumination. Both endogenous and exogenous stimulation promote Fenton/Fenton-like reaction simultaneously. Second, establish the drug safety evaluation system through the data of in vivo and in vitro toxicity, distribution and excretion, pathology of main organs and blood biochemical indicators of nanocomposites. Third, NIR-II fluorescence imaging of rare-earth luminescent materials could monitor the treatment process in real time due to the advantages of tissue penetration depth and resolution. This project aims to construct a kind of effective photothermal/chemodynamic synergistic anti-cancer treatment systems triggered by the tumor microenvironment and guided by NIR-II fluorescence imaging. The promotion mechanism of endogenous and exogenous stimulation for “Chemodynamic Therapy” will be investigated to provide theoretical basis for researches of such systems in the future.