临床上与肠神经系统缺陷有关疾病很多，但大多数病理生理并不清楚。尽管在中枢神经系统(CNS)中，Neurexin 与Neuroligin基因已经被证实支配突触的发生、发育与功能，但对肠神经系统(ENS)突触的构成知之甚少。既然ENS与CNS关系密切，其突触发生机理也极可能十分相似，那ENS中突触功能和发育的异常就可以解释胃肠道的机能紊乱。笔者已初步证实：Neurexin与Neuroligin基因在鼠类及人体肠管都有表达，说明它们对ENS突触功能也起重要作用。下一步将对Neurexin与Neuroligin基因与肠神经系统的发育以及疾病的发生机理作深入研究。基础实验与临床研究相结合，将对ENS突触的形成、发育、功能有很好的揭示，对ENS发育缺陷做出深入探讨，对胃肠动力性障碍等肠神经缺陷性疾病的机理做出一定的解释，对先天性巨结肠等相关疾病的诊断、治疗与预防有重大意义。

The pathogenesis of many diseases about the developmental defects of enteric nervous system(ENS) is still not clear．We kown very little about the function of the synapse in ENS,though Neurexin and Neuroligin have been confirmed that they play an important role in the development and function of synapse in central nervous system(CNS).We kown that ENS has a close relationship with CNS and the synaptic mechanism of ENS must be very similar with CNS.As a result,the functional disturbance of gastrointestinal tract could be indicated by the dysplasia and disfunction of synapse in ENS.We have preliminarily confirmed by double immunofluorescence technique that Neurexin and Neuroligin are expressed in the ENS of human and rodents,which show that Neurexin and Neuroligin also play an important role in the synapic function．Followed that， we will further sdudy the role of Neurexin and Neuroligin in the development of ENS and the pathogenesis of many diseases by the experimental methods of in situ hybridization，RT-PCR,real-time fluorescence quantitative PCR,gene sequencing,cell culture,serological detection and so on.Finally,we will reveal the formation,development and function of synapse in ENS,further discuss the developmental defects of synapse and elucidate the pathogenesis of diseases with functional disturbance of gastrointestinal such as Hischsprung's disease(HD) which has important significance to the diagnosis,treatment and prevention of these diseases.