低级别胶质瘤是大脑内侵袭性恶性肿瘤，发病率约为40/10万。部分低级别胶质瘤患者会出现肿瘤恶性转化，早期难以及时诊断并进行早期干预，极大缩短了患者的生存期。TP53是重要的抑癌基因，其异常表达会诱导肿瘤细胞侵袭性增高、凋亡水平下降；其次ATRX基因突变会造成胶质瘤细胞端粒酶失活，最终诱导低级别胶质瘤发生恶性转化。影像基因组学通过挖掘肿瘤影像多维度生物信息，研究基因表达/突变与影像特征之间关系。本研究通过动物模型研究TP53和ATRX基因表达差异对影像表型的影响；其次应用多模态PET/MR成像技术，研究肿瘤恶性进展中TP53和ATRX基因表达异常与肿瘤影像纹理特征的关联，进而应用PET/MR影像基因组学方法对低级别胶质瘤患者肿瘤恶性进展进行预测评估。

Low-grade gliomas are invasive malignant tumors in the brain with an incidence of about 40/100,000. Some patients with low-grade gliomas will suffer tumor malignant transformation, it is difficult to diagnose and intervene in the early stage, which greatly shortens the survival time of the patients. TP53 is an important tumor suppressor gene, and its abnormal expression can induce increased invasiveness and reduce apoptosis levels of tumor cells; Secondly, ATRX gene mutation will cause telomerase inactivation in glioma cells, and finally induce malignant transformation of low-grade gliomas. In this study, animal models were used to study the effects of differences in TP53 and ATRX gene expression on imaging phenotypes. Second, multimodal PET/MR imaging technology was used to study the association between abnormal expressions of TP53 and ATRX genes and the texture characteristics of tumor images during malignant tumor progression; furthermore, the PET/MR imaging genomics method was used to predict the malignant tumor progression in patients with low-grade gliomas.