知觉学习是大脑神经可塑性的行为表现，它是认知神经科学的一个重要领域。申请人近年运用创新性的“双训练”实验范式，验证了知觉学习能够迁移到未训练的网膜位置、特征、在不同神经元编码的物理刺激等，表明知觉学习可能是发生在高级脑区的认知学习，并初步提出了新的概念学习理论。工作发表于Nat. Neurosci., PLoS Biol., Cur. Biol., J. Neurosci.,eLife等杂志并产生了重要的学术影响。本项目拟继续深入地研究知觉学习及其认知机制，检验、丰富和发展概念学习理论，并在理论指导下开展视觉疾病（如弱视）知觉学习基本机制与临床应用的研究。具体研究内容包括：（1）双训练范式下知觉学习跨模态迁移的机制；（2）Triple training范式下知觉学习跨二维特征的迁移机制；（3）对不同刺激证据进行抽象—新的知觉学习形式的探索；（4）成人和儿童弱视双眼知觉学习的机制与应用研究。

Perceptual learning refers to the process to improve sensory discrimination through training. Perceptual learning reflects the neural plasticity of the brain and is one of the important areas in cognitive neuroscience. In the recent years, the applicant developed an innovative double training paradigm, and demonstrated that perceptual learning often completely transfer to new retinal locations, orientations and physical stimuli that are initially encoded by different neuronal mechanisms. These findings indicate that perceptual learning is a high-level process that operates at an abstract conceptual level. The applicant thus proposed a new concept theory and published in Nature Neuroscience, PLoS Biology, Current Biology, J. Neuroscience, eLife and other influential journals. The proposed research will continue to investigate perceptual learning and its cognitive and brain mechanisms and test and improve the concept theory, as well as study the mechanisms of perceptual learning in amblyopia. The specific topics include 1) the cross-modal learning transfer with double training paradigm; 2) the transfer of perceptual learning to a physically and orientation different stimulus with triple training paradigm; 3) A new format of perceptual learning that abstracts stimulus evidence from multiple stimulus conditions; 4) the mechanisms and applications of dichoptic perceptual learning in adults and children with amblyopia.