非人类灵长类大型哺乳动物已广泛应用在包括临床医学的生命科学研究，但相关的MRI研究还在低场下展开。本申请将依托强磁场科学中心的9.4 T 40 cm大型哺乳动物磁共振成像装置，围绕猴子等非人类灵长类大型哺乳动物，开发一系列与脑结构及功能连接研究相关的关键的高场成像技术与谱学方法，其中包括相位成像新技术、磁敏感张量成像技术、SSFP功能成像方法、抗磁场畸变的iMQC高分辨谱学技术等。研究目标是系统探索高场下的相位成像的机制与机理、SSFP功能成像的理论基础、以及活体生物代谢与脑结构和功能的关系。本项目的执行将为临床医学和生命科学提供重要的新颖的技术，而高场成像和谱学技术的研究、非人类灵长类大型哺乳动物的脑功能结构与功能连接也具有重要的学术意义和应用前景。

Large mammalians, including non-human primates (NHP), have been widely used in life science research. MRI study on NHPs is currently carried out under low magnetic field. This proposal will use the advanced 9.4 T wide-bore MRI facility at High Magnetic Field Lab (HMFL) to study the connectivity between brain structure and brain function in large NHP animal models. The key MR imaging and spectroscopic methods that will be developed include phase imaging, susceptibility tensor imaging, SSFP functional imaging, and inter-molecular multi-quantum (iMQC) spectroscopy. The research aim is to explore the high field phase imaging mechanism, the theoretical basis of the SSFP functional imaging, as well as brain metabolism and brain function. The implementation of the project will provide important new imaging tools for clinical and life sciences research. Studies in the connectivity between brain structure and brain function in large NHP also give new insight into the understanding of the human brain.