本研究应用1:1匹配的前瞻性巢式病例对照研究设计，探讨脂肪酸代谢通路MFGE8基因和CD36基因多态性与汉族人群代谢综合征关系的遗传关联。通过对466名代谢综合征患者和466对照进行行为危险因素的问卷调查、人体测量、脂质和糖代谢等指标的检测，选择脂肪酸代谢通路MFGE8基因和CD36基因 "标签SNP位点"和其他人群中发现的阳性位点，拟在我国汉族人群中研究脂肪酸代谢通路MFGE8基因和CD36基因与代谢综合征及其组分的遗传关联强度，分析脂肪酸代谢通路MFGE8基因和CD36基因以及上述基因与行为危险因素间的交互作用，筛选我国汉族人群代谢综合征及其组分的遗传标志物，为进一步探索心血管代谢疾病发病机制提供科学证据。

A perspective nest case - control study is employed to investigate association between gene （MFGE8 and CD36）polymorphism and metabolic syndrome (MS) risk and components of MS. The questionnaire interview for behaviroral risk factors, anthropometric measurements and metabolic indexes such as lipid index and glucose index, will be carried out for 466 patients with MS and 466 healthy participants. Tag SNPs loci of fatty acid metabolic signaling pathway genes (MFGE8 and CD36 ) and those positive sites, which have been explored in other population, are selected to determine genetic association between fatty acid metabolic signaling pathway genes and MS and components of MS in the Chinese han people. Additionally, we can analyze the interaction between the fatty acid metabolic genes and behaviroral risk factors, screen the genetic markers of MS and components of MS in Chinese Han population, and then provide scientific evidence for further exploration the pathogenesis of cardiovascular metabolic disease.