皮肤鳞状细胞癌（CSCC）是常见的皮肤恶性肿瘤之一，风险因素主要包括紫外线照射、人类乳头瘤病毒（HPV）感染、免疫抑制以及慢性皮肤炎等，但尚不十分清楚其致病机制。本课题组前期发现新疆地区大部分CSCC患者生活在紫外线强，HPV感染高发的新疆南部地区（南疆），初步探讨了HPV感染与皮肤鳞癌的关系以及Wnt信号转导通路中抑制因子SFRPs家族甲基化状态及其在CSCC中可能的作用机制。在以上工作基础上，本课题组拟采用亚硫酸盐克隆测序，RT-PCR，siRNA干扰等实验方法从临床样本、细胞模型水平分析研究新疆地区维、哈、汉族皮肤鳞癌的临床病理特征及发病机制，阐明UV照射和HPV感染协同调控DNA甲基化诱发CSCC的作用机制，以寻找早期诊断及早期治疗的新靶点。

Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignant skin tumors.The risk factors include ultraviolet radiation,human papillomavirus (HPV) infection,immunosuppression,and chronic dermatitis,etc. But it is not clear about the pathogenic mechanism. In our previous study,we founded that most of the patients with CSCC in Xinjiang area lived in the southern area of Xinjiang with strong ultraviolet radiation and high HPV infection. We discussed the relationship and the possible mechanism between HPV infection and CSCC,the methylation status of SFRPs in the Wnt signal transduction pathway in. On the basis of above work, our group intends to use sulfite cloning and sequencing, RT-PCR, siRNA interference experiment method from the model level of clinical samples, cells,animal to analysis clinical pathological characteristics of the patients with CSCC in Xinjiang.To object elucidate the molecular mechanism of DNA methylation induced cutaneous squamous cell carcinoma by coordinated regulation of UV radiation and HPV infection in Xinjiang, in order to find a new target for early diagnosis and early treatment.