冠心病严重危害我国人民身体健康，其发病率和病死率仍呈明显上升趋势，而且越来越显示年轻化。目前已知的冠心病传统危险因素，如高脂血症、糖尿病、高血压、吸烟，不能完全解释冠心病的发生和发展过程。因此，探究新的冠心病危险因素十分迫切。近期有研究发现，肠道微生物可以通过代谢途径以及炎症途径加速动脉粥样硬化形成。我们的研究将通过对比不同冠心病亚型患者肠道菌群结构特点，寻找与冠心病发生发展高度相关的肠道菌群结构特征，并在验证队列中验证。此外，我们还将明确代谢途径以及炎症途径在其中所起到的作用，并在动物模型中验证。最终希望通过明确中国人群肠道菌群结构和冠心病不同亚型之间的关系，为冠心病的预防和诊疗提供新的手段。

The morbidity and mortality of coronary heart disease (CHD) are increasing in recent years and seriously threaten the health of Chinese people. What's more, more and more younger people are suffering from CHD. Currently known risk factors of CHD, such as hyperlipidemia, diabetes, hypertension and smoking, cannot fully explain the pathogenesis and development of CHD. Therefore, it is extremely urgent to explore new CHD risk factors. Recent studies have found that intestinal microbes accelerate atherosclerosis formation through both metabolic and inflammatory pathways. Our study aims to find out intestinal microflora characters which are highly related to the development of CHD by comparing the intestinal microflora characters of patients with different CHD subtypes, and then verify these findings in a cohort. In addition, we also want to explicit the roles of metabolic and inflammatory pathways in the process of atherosclerosis formation and verify them in animal models. Eventually we hope to clarify the relationship of intestinal microflora and different subtypes of CHD among Chinese people, and provide a new diagnostic tool and a precaution for CHD.