流行病学资料显示高温对人群的影响具有地区相对性，热适应是形成这种现象的重要原因，而热适应的产生与热应激蛋白的高表达相关。本研究拟以"热邪"为代表，利用气候模拟，观察不同基础温度适应相同最高温度应激、不同基础温度适应相同温差应激、不同温度上升速度应激对大鼠肛温、死亡率、HSP70的影响阐明"六淫"的产生具有相对性，相同气候变化对某些人群而言是"六气"，对某些人群而言是"六淫"，导致这种差异的主要原因是机体的应激和适应反应，对气候异常变化相关性疾病的预防不可只局限于气象预报等行为，应把机体应激和适应反应的干预作为下阶段的重要目标。身为中医药研究人员则应开发利用中医丰富的"六淫学说"内容调节机体应激和适应反应，使其向机体有利的方向发展。本研究同时检测分析HSP70在热应激和热适应中的变化规律，以期为利用中医药干预机体应激和适应反应提供切入点。

Datas in epidemiology showed that the influence of high temperature on groups had the relativity of regions, which was caused by heat adaptation significantly. Meanwhile, heat adaptation was related with the high expressions of heat stress proteins. With climatic simulation, we plan to observe the changes of rats' rectal temperature, mortality and HSP70 level induced by three types of temperature changes: the different basic with the same highest temperature, the different basic temperature with the same temperature difference and the different speeds of temperature increase. We try to interpret that Six climatic pathogens have relativity which results in physical stress and adaptation, so we should have to pay more attention to the intervention on physical stress and adaptation than weather forecast. As researchers of Chinese medicine, we should adjust physical stress and adaptation to a advantageous direction with the ample theory of six climatic pathegens. The change rules of HSP70 in stress and adaptation will be detected and analyzed to provide a breakthrough point for using Traditional Chinese Medicine in that.