昆虫翅表面是自然界最复杂的三维周期性介质结构之一，是理想的仿生研究材料和人工复制模版。基于仿生耦合理论，本项目利用表面微纳结构制备技术和分子设计方法，构建抗生物粘附的仿生耦合材料表面，建立材料-结构-形态-功能一体化的仿生耦合模型，实现多形态、多尺度的仿生材料表面可控设计和制备。通过仿生材料表面表征和特定环境条件下抗生物粘附性能的评价与分析，建立化学组成-微纳结构-物理化学参数-抗生物粘附性能之间的构效关系，揭示微纳结构和化学性质对仿生材料表面生物粘附性能的作用机制。在细胞尺度、纳米尺度、分子尺度阐明仿生材料表面抗生物粘附行为的影响因素、理化基础和生物响应性，完善表面抗生物粘附的理论体系，为特殊浸润性表面材料的仿生设计提供新的思路和途径，实现从自然界的生物原型到工程界的仿生耦合。

Insect wing surface is one of the most complex three-dimensional periodic medium structure, which is an ideal material for biomimetic research and template for artificial duplication. Based on bionic coupling theory, in this project preparation technology of surface micro/nano structure and molecular design method are utilized, anti-bioadhesive surfaces are established, the integrated material-structure-form-function biomimetic coupling models are developed, controllable design and fabrication of multi-form and multi-scale biomimetic surfaces are achieved. Based on the characterization of biomimetic surfaces, assessment and analysis of anti-bioadhesive performance under given conditions, the relationship of chemical composition-micro/nano structure-physical chemistry parameters- anti-bioadhesive performance is built up, the mechanism of micro/nano structure and chemical property on anti-bioadhesive performance of biomimetic surface is revealed. On the scales of cell, nanometer, and molecule, the influencing factors, physical and chemical basis, biological response of anti-bioadhesive performance of biomimetic surface are expounded, the theoretical system of surface anti-bioadhesive property is improved. It aims to provide novel idea and approach for biomimetic design of surface material with special wettability and realize the conversion from biological prototype in nature to biomimetic coupling in engineering.