导向基团介导的金属卡宾的高选择性分子间C-H插入反应研究

金属催化剂促进的重氮化合物分子间C-H插入反应是构建C-C键的重要方法，然而由于存在竞争性副反应和区域选择性问题，多数情况下该类反应不能获得好的收率和区域选择性，因此限制了其在有机合成中的应用。我们拟采用引入定位基团的方法，通过其与过渡金属催化剂的配位，引导重氮化合物分解后形成的金属卡宾对底物中特定的C-H键发生插入反应，显著提高反应的区域选择性和化学收率。通过对重氮化合物结构、定位基团的性质、催化剂的性质以及底物结构的深入研究，发展高效、广谱、具有高度区域选择性的分子间C-H插入反应。此外，也计划采用手性催化剂或手性定位基团，进一步控制反应的对映选择性，发展有效的不对称C-H插入新方法。

The catalytic intermolecular C-H insertion reaction of diazo compound is one of the great challenges in directly C-C formation.The applications of selective intermolecular C-H insertion with diazo compounds in organic synthesis are still rare probably due to the competed reactions and poor regioselectivities. We will explore on the selective intermolecular C-H insertion of metal carbene with the help of directing-group. The existing directing-group can be used to chelate the metal catalyst and position it for selective C-H insertion. Precoordination can greatly improved the regioselevtivity and reactivity.By exploring on the structure of diazo compounds and the substrates,the nature of directiong-groups and catalysts, we will develop a high-selective,high-reactive and widely used intermolecular C-H insertion. This kind of reactions on the synthesis of chiral compounds will also be explored by adding chiral catalysts or chiral directing group.