2型糖尿病是一组以慢性高血糖为特征的代谢性疾病，其病理生理学机制主要包括：胰岛素抵抗、高血糖及不同程度的胰岛素功能缺陷。长期口服降糖药，不仅会增加肝肾代谢功能的负担，还会导致某些恶性肿瘤的发生。因此，探讨一种新型的治疗2型糖尿病的方法，对降低长期口服降糖药的远期并发症具有重大作用。研究表明，交感神经系统参与调节体内物质代谢和能量平衡，其慢性激活与胰岛素抵抗以及2型糖尿病等代谢紊乱密切相关。肾交感神经射频消融术可通过降低交感神经活性有效治疗顽固性高血压，因此我们推测肾交感神经射频消融术可以降低交感神经活性，减轻胰岛素抵抗，从而有望控制2型糖尿病患者的血糖。本项目在前期研制多电极肾动脉射频消融导管的基础上，将其应用于2型糖尿病犬模型中，探讨肾交感神经射频消融术治疗2型糖尿病的可行性和疗效性，进而为临床应用提供理论及实验依据。

Type 2 diabetes mellitus is a group of metabolic diseases characterized by impairment in glucose, whose pathophysiology includes insulin resistance, hyperglycemia and a variable degree of insulin secretory deficiency. Long-time hypoglycemic agents taken may not only increase the burden of the liver and kidney, but also lead to the occurrence of some malignant neoplasms. Therefore, it is vital to explore a new method to treat type 2 diabetes mellitus and to reduce the complications of long-time taking oral medicine. Researches showed that the sympathetic nervous system was involved in regulating metabolism and energy balance in vivo, and its chronic activation associated closely with insulin resistance, type 2 diabetes and other metabolic disorders. Renal denervation can treat resistant hypertension via reducing sympathetic nerve activity, thus we presume renal denervation may reduce sympathetic nerve activity and insulin resistance, and then improve glycaemic control in type 2 diabetes mellitus patients. In this study, based on the previous researches on developing a new type of multi electrode catheter for renal denervation, we will apply this catheter to canine with type 2 diabetes mellitus to investigate the feasibility and effect of renal denervation treating type 2 diabetes mellitus, and provide theoretical and experimental basis for clinical application.