以环境中累积量高的稀土离子[Ln(III),Ln=La、Ce]和模式植物拟南芥为典型代表；以揭示Ln(III)活化植物胞吞作用的靶分子及其机制为研究目的；以细胞化学(稀土放射自显影技术等)、计算化学(细胞环境分子动力学模拟及量化计算)、细胞生物学(细胞活体分子标记、全内反射荧光显微镜、隐失波荧光显微镜及激光扫描共聚焦显微镜等技术)、分子生物学(诱导突变体等技术)与物理化学(自主组装细胞电化学系统、近边X射线吸收精细结构、电子探针X射线微区分析等多种谱学技术)方法的优化组合为研究手段；以探究Ln(III)活化植物胞吞作用的靶分子-信号转导及途径(基因表达)-调控过程及细胞响应（生长）间关系为研究内容；阐明Ln(III)活化植物胞吞作用的首要靶分子、信号转导与调控过程、细胞响应及生长变化及其关系的机制，为从细胞及分子层次揭示稀土离子作用于植物的机理及其食品安全国际标准的建立提供借鉴。

The wide application of rare earth elements has caused the accumulation of rare earth elements in ecosystem, including soil, atmosphere and water. The rapid development of rare earth industry and the wide application of rare earth elements have made it urgent to elucidate the cytobiological and cytochemical mechanisms of rare earth elements action on living organisms to ensure the quality and security of food, human health and environmental safety. However, the cellular mechanism remains unclear although scientists have extensively investigated the effect of rare earth ions upon cells since 1917. In the proposal, Arabidopsis (Arabidopsis thaliana L) and Ln(III)（Ln=La,Ce）which had been over accumulated in ecosystem will be chosen as a typical representative of the model plant and rare earth elements respectively. According to the results from our experiments in the project supported by Natural Science Foundation of China(20971069), here, we aim to reveal the mechanism and target molecules of Ln(III) activating endocytosis in the plant cells. In order to achieve the research purpose, these questions on which of molecules in the space between the cell wall and plasma membrane are given priority to coordinate Ln(III), how to activate the endocytosis of plasma membrane in plant, how to transfer signal, how to control the gene expression, how to regulate cytobiological responses and the growth of cells etc.,would be further investigated with optimizing combination of cytochemical means(EMARG etc.), computational chemistry(molecular dynamics simulation, quantum chemical calculation), cytobiological technique (FM, TIRFM, EWFM, LSCM etc.), molecular biology method (DN,CA etc.), and physicochemical technique (DPV, EXAFS, EPMA etc.). The results would provide some new thinking and references for scientifically assessing the damage of the accumulation of rare earth elements in biosystem to crop. They also would provide guide for establishing the international standard of rare earth elements limitation in plants and food.