长链非编码RNA(long non-coding RNA, lncRNA)在肿瘤发生发展中发挥重要调控作用，其在胃癌中的研究尚处于初始阶段，相关研究鲜有报道。明确目标lncRNA的调控机制是研究的难点和关键，近程调控邻近编码蛋白基因是lncRNA重要调控手段之一。我们的前期研究结果显示：1）lncRNA-LINC00628和上游248KB处的LRRN2基因在胃癌中均异常高表达，且表达水平与TNM分期相关；2）LINC00628和LRRN2在胃癌中表达正相关，干扰或过表达LINC00628后LRRN2表达水平均发生相应变化。基于上述结果，我们拟进一步从近程调控角度明确lncRNA-LINC00628对LRRN2基因的调控作用、研究两者在胃癌中的功能、探索相关信号通路和作用机制、明确与预后关系。进一步为寻找新的预后指标和治疗靶点提供新思路，也为lncRNA靶基因的研究提供方法和依据。

Long non-coding RNAs play critical roles in the progression of a variety of tumors. Up to now,the precise functions of lncRNAs in gastric cancer (GC) have rarely been studied. Understanding of the roles of lncRNAs in GC would help reveal the mechanisms of tumor development and provide new therapeutic methods in GC. However,it is difficult and critical to study the concrete regulation mechanisms of lncRNAs. According to recent literatures, regulating the neighoring protein-coding genes is an important regulation mechanism of several lncRNAs. Previous studies in our laboratory revealed that lncRNA-LINC00628 and its neighboring gene LRRN2 were both upregulated in GC and correlated with TNM stage. Also, we observed positive correlation between levels of LINC00628 and LRRN2 expression and the phenomenon that deletion of LINC00628 led to decreased expression of LRRN2. Based on these findings, we will go furthor to study the role of LINC00628 and LRRN2 in GC and their relations to patient's prognosis. Furthermore, we are going to research the underlying regulation mechanisms and related signaling pathways, and provide promising therapeutic methods for GC treatment.