肟具有来源广泛、容易制备、稳定性好和毒性低等优点。鉴于肟氮-氧键键能较低，探索肟氮-氧键新的化学转化途径将创造出许多新化合物。最近，申请人课题组围绕肟氮-氧键的催化转化，发现了几类新的反应类型：环状肟酯与异腈反应合成嘧啶二酮类化合物、酮肟醚与烯烃反应构建新的碳碳双键、酮肟酯与烯烃发生环加成反应构建螺环骨架、酮肟酯与马来酰亚胺反应构建多环含氮骨架。本课题将在这些结果的基础上，系统研究肟新的化学转化途径，为重要有机分子的制备提供高效、实用的合成方法。研究内容包括：肟参与的多种杂环体系的构建、碳碳双键的构建、羰基远端碳-氢键的官能团化。这些研究将极大的丰富和拓展肟氮-氧键的化学转化类型。此外，反应涉及的过渡金属络合物和配体的合理设计与合成、多种活性中间体的反应性等基础问题的深入探索和解决将为我们合理设计和发展出更多的新型催化反应提供重要的参考和打下坚实的基础。

Oximes generally possess several advantages, including wide availability, easy accessibility, good stability, and low toxicity. Considering the generally low bond energy of the oxime N–O bond, it will have many opportunities to create numerous organic compounds through the realization of new chemical transformations of oxime N–O bond. Recently, our research interests focus on the catalytic transformations of the oxime N–O bond, and have found some new organic reactions which include the synthesis of pyrimidinediones through the reaction of cyclic oxime esters and isocyanides, the generation of new C=C bond through the reaction of ketoxime ether and olefin, and the construction of spirocyclic scaffolds and polycyclic N-heterocycles from ketoxime ester and olefin or maleimide, respectively. Based on these results, we will systematically study the new chemical transformations of oxime N–O bond, which will provide efficient and practical methods for the preparation of important organic molecules. The contents of this project contain the construction of several heterocyclic skeletons, the generation of C=C bond, and remote C-H bond functionalization of carbonyl compounds. The realization of these organic reactions will significantly enrich the transformations of the oxime N–O bond. In this project, we will solve various problems, e.g., rational design of transition metal complexes and ligands, and improvement of the reactivity of many reactive intermediates. The systematic studies on these problems and success in realizing the desired reactions will prompt us to design and develop more new synthetic methods.