炎症反应在糖尿病周围神经病变(DPN)发生中起着重要作用。JNK/SAPK通路与DPN的发生密切相关，多种因素（如炎症因子等）可激活此通路，使神经细胞功能和结构发生可塑性改变，导致DPN的发生。课题组前期临床和实验发现具活血化痰通络的药物通络糖泰可改善DPN患者和动物模型糖脂代谢，降低血清相关炎症因子及改善神经症状或神经传导速度。我们推测通络糖泰可能通过调控JNK通路起作用，下调JNK的表达，抑制JNK信号通路，减轻大鼠背根神经节神经细胞缺氧高糖损伤及糖尿病大鼠周围神经病变。因此，通过在体和细胞培养的方法，运用神经电生理、p-JNK免疫组织化学、RT-PCR等手段，研究通络糖泰是否对自发性2型DPN大鼠在体、离体神经组织的JNK信号转导通路有影响，确定其作用此通路的可能靶点，并观察其对雪旺细胞的可能影响，从全新的角度阐释该治法治疗DPN的疗效机制，为中医药治疗DPN开辟新的思路和方法。

Inflammatory response around the disease of Diabetic peripheral neuropathy（DPN） plays an important role in the occurrence. JNK/SAPK signal pathway is closely related to DPN, A number of factors can activate this pathway,change the structure and function of Nerve cells. Research Group found Tongluotangtai could improve Glucose and Lipid metabolism, reduce the blood serum related inflammation factor , improve nerve symptom and nerve conduction speed of the patients or animal models in the pre-clinical and experimental. We surmise that Tongluotangtai may through regulate JNK pathway work .So , through in body and cell raise method, We study whether Tongluotangtai can effect the JNK signal pathway of the spontaneous type 2 DPN rat, and observe its effects on Schwann cells ,study the nature of modern science of the reatment from a new angle.