抑郁症是危害人体心理和生理健康的疾病。采用西药治疗抑郁症可部分改善症状，但存在治愈率低和不良反应等问题。而运用中医药治疗抑郁症不仅可改善症状，并且副作用小。但由于中药成分复杂，导致其治疗效应机制尚不明确。网络药理学和分子对接技术的发展，为中药复杂成分的生物作用效应研究提供了研究方法。最近，研究表明，抑郁症是一类小胶质细胞调控失调的神经系统疾病。因此，本研究将探究中医药对抑郁症小胶质细胞模型的调控作用，从而为中医药治疗抑郁症提供新的思路和研究基础。本项目拟采用复杂网络技术挖掘中医药治疗抑郁症的核心药物，利用网络药理学和分子对接技术探寻核心药物中的活性成分对小胶质细胞异常激活或衰减的调节，以揭示核心中药抗抑郁的可能机理。该研究将明确核心中药治疗抑郁症的起效途径，为中医药防治抑郁症提供理论依据，并为新药研发提供证据支持。

The depression threatens human physical and mental health. Although modern antidepressant medication partially improves symptoms, it still causes low efficiency and common side effects. Traditional Chinese medicine (TCM) has a significant effect on depression with fewer side effects, but the function mechanism is still covered. The Complex Network and Molecular Docking is more commonly used by researcher to elucidate the biofunction of the TCM. Currently, the depression is believed as a central nervous system disordering disease that is caused by dysregulated microglia. Therefore, in this research project, we aim to detect whether the TCM regulates microglia to cure the depression by network screening, complex Network, molecular Docking, and cell biology research, which will offer the new strategy and information for treatment depression.