二补助育汤是名老中医肖承悰教授治疗子宫内膜容受性低的独特经验方，前期临床研究表明，其能明显改善子宫内膜容受性，提高再次IVF-ET妊娠成功率；前期实验研究表明，中药可能通过SCF、LIF、ER、PR、整合素ανβ3、HOXA-10等参与胚胎植入的黏附过程，从而影响子宫内膜容受性。为进一步阐明中药对胚胎植入定位、黏附、侵入过程的影响，我们提出NK/M-CSF/NO通路，采用吲哚美辛方案制备动物模型，应用硝酸还原酶法、Real-time PCR、流式细胞仪等技术，研究二补助育汤对子宫内膜该通路及胞饮突表达的影响，从而进一步揭示以"补肾气，通胞脉"立法之中药提高子宫内膜容受性的作用靶点和整体效应机制，为临床提高IVF-ET受孕率提供实验及理论依据。

Erbuzhuyu decoction is the unique experienced prescription of the senior TCM Professor Xiao Chengcong of low endometrial receptivity treatment, early clinical studies have shown it can significantly improve the receptivity of the endometrium, and promote the success rate of IVF-ET pregnancy.Early experimental studies have shown that traditional Chinese medicine may be involved in the adhesion process of embryoim plantation by SCF, LIF, ER, PR, ανβ3, HOXA-10,so as to affect endometrial receptivity. To clarify further research on the position adhesion,and invasion on embryo implantation, we suppose NK/M-CSF /NO pathway, using mouse models made by indomethacin solution, on nitrate reductase method, on Real-time PCR method and flow cytometry instrument to research Erbuzhuyu decotion's influence on NK / M-CSF / NO pathway and pinopode expression. To clarify the targets effect and overall mechanisms on behalf of the TCM prescriptions to improve the pregnancy rate of IVF-ET，and figure out the mechanism of "nourishing the Qi of kidney with filling up the vessels of uterus" which may provide the experimental and theoretical basis for clinical improve the pregnancy rate in IVF-ET.